PLATELETS AND THROMBOPOIESIS Polymorphisms of protein tyrosine phosphatase CD148 influence Fc RIIA-dependent platelet activation and the risk of heparin-induced thrombocytopenia
نویسندگان
چکیده
1Unité Mixte de Recherche Centre National de la Recherche Scientifique 7292 and Université François Rabelais, Tours, France; 2Laboratoire d’Hématologie-Hémostase, Centre Hospitalier Universitaire (CHU) Tours, Tours, France; 3Inserm, U1048 and Université Toulouse 3, I2MC, Toulouse, France; 4Service d’Anesthésie-Réanimation, CHU Tours, Tours, France; 5Service de Chirurgie Cardiaque, CHU Tours, Tours, France; 6Laboratoire d’Immunologie, CHU Tours, Tours, France; and 7Laboratoire d’Hématologie, CHU Toulouse, Toulouse, France
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Platelets play a fundamental role in hemostasis and thrombosis. They are also involved in pathologic conditions resulting from blocked blood vessels, including myocardial infarction and ischemic stroke. Platelet adhesion, activation, and aggregation at sites of vascular injury are regulated by a diverse repertoire of tyrosine kinase–linked and G protein– coupled receptors. Src family kinases (S...
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1Institut für Immunologie und Transfusionsmedizin, Ernst-Moritz-Arndt Universität, Greifswald, Germany; 2Genetik der Mikroorganismen, Interfakultäres Institut für Genetik und Funktionelle Genomforschung, Ernst-Moritz-Arndt Universität, Greifswald, Germany; 3Klinik und Poliklinik für Allgemeine Chirurgie, Viszeral-, Thoraxund Gefässchirurgie, Ernst-Moritz-Arndt Universität, Greifswald, Germany; ...
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